BP103T. PHARMACEUTICS- I – PCI SYLLABUS

Scope 

• This course is designed to impart a fundamental knowledge on the preparatory pharmacy with arts and science of preparing the different conventional dosage forms.

Objectives

• Upon completion of this course the student should be able to:
  • Know the history of profession of pharmacy
  • Understand the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations
  • Understand the professional way of handling the prescription
  • Preparation of various conventional dosage forms

Course Content

UNIT – I 

• Historical background and development of profession of pharmacy
  • History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career
  • Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.
• Dosage forms
  • Introduction to dosage forms, classification and definitions
• Prescription
  • Definition, Parts of prescription, handling of Prescription and Errors in prescription.
• Posology
  • Definition, Factors affecting posology. Pediatric dose calculations

UNIT – II 

• Pharmaceutical Calculations:
  • Weights and measures – Imperial & Metric system
  • Calculations involving percentage solutions, alligation, proof spirit and isotonic solutions based on freezing point and molecular weight.
• Powders:
  • Definition, classification, advantages and disadvantages
  • Simple & compound powders – official preparations, dusting powders, effervescent, efflorescent and hygroscopic powders, eutectic mixtures.
  • Geometric dilutions.
• Liquid Dosage Forms:
  • Advantages and disadvantages of liquid dosage forms.
  • Excipients used in formulation of liquid dosage forms.
  • Solubility enhancement techniques

UNIT – III  

Monophasic Liquids:

• Definitions and preparations of Gargles, Mouthwashes, Throat Paint, Eardrops, Nasal drops, Enemas, Syrups, Elixirs, Liniments and Lotions.

Biphasic Liquids:

• Suspensions:
  • Definition, advantages and disadvantages, classifications, Preparation of suspensions;
  • Flocculated and Deflocculated suspension & stability problems and methods to overcome.
• Emulsions:
  • Definition, classification, emulsifying agent, test for the identification of type of Emulsion
  • Methods of preparation & stability problems and methods to overcome.

UNIT – IV 

Suppositories:

• Definition, types, advantages and disadvantages, types of bases, methods of preparations.
• Displacement value & its calculations, evaluation of suppositories.

 Pharmaceutical Incompatibilities:

• Definition, classification, physical, chemical and therapeutic incompatibilities with examples.

UNIT – V

Semisolid Dosage Forms:

• Definitions, classification, mechanisms and factors influencing dermal penetration of drugs.
• Preparation of ointments, pastes, creams and gels.
• Excipients used in semi solid dosage forms.
• Evaluation of semi solid dosages forms

Recommended Books: (Latest Editions) 

• C. Ansel et al., Pharmaceutical Dosage Form and Drug Delivery System, Lippincott Williams and Walkins, New Delhi.
• Carter S.J., Cooper and Gunn’s-Dispensing for Pharmaceutical Students, CBS publishers, New Delhi.
• E. Aulton, Pharmaceutics, The Science& Dosage Form Design, Churchill Livingstone, Edinburgh.
• Indian pharmacopoeia.
• British pharmacopoeia.
• Theory and Practice of Industrial Pharmacy,Lea& Febiger Publisher, The University of Michigan.
• Alfonso R. Gennaro Remington. The Science and Practice of Pharmacy, Lippincott Williams, New Delhi.
• Carter S.J., Cooper and Gunn’s. Tutorial Pharmacy, CBS Publications, New Delhi.
• A. Rawlins, Bentley’s Text Book of Pharmaceutics, English Language Book Society, Elsevier Health Sciences, USA.
• Isaac Ghebre Sellassie: Pharmaceutical Pelletization Technology, Marcel Dekker, INC, New York.
• Dilip M. Parikh: Handbook of Pharmaceutical Granulation Technology, Marcel Dekker, INC, New York.
• Francoise Nieloud and Gilberte Marti-Mestres: Pharmaceutical Emulsions and Suspensions, Marcel Dekker, INC, New York.