BP103T. PHARMACEUTICS- I – PCI SYLLABUS

 

Scope 

  • This course is designed to impart a fundamental knowledge on the preparatory pharmacy with arts and science of preparing the different conventional dosage forms.

Objectives

  • Upon completion of this course the student should be able to:
    • Know the history of profession of pharmacy
    • Understand the basics of different dosage forms, pharmaceutical incompatibilities and pharmaceutical calculations
    • Understand the professional way of handling the prescription
    • Preparation of various conventional dosage forms

Course Content

UNIT – I 

  • Historical background and development of profession of pharmacy
    • History of profession of Pharmacy in India in relation to pharmacy education, industry and organization, Pharmacy as a career
    • Pharmacopoeias: Introduction to IP, BP, USP and Extra Pharmacopoeia.
  • Dosage forms
    • Introduction to dosage forms, classification and definitions
  • Prescription
    • Definition, Parts of prescription, handling of Prescription and Errors in prescription.
  • Posology
    • Definition, Factors affecting posology. Pediatric dose calculations

UNIT – II 

  • Pharmaceutical Calculations:
    • Weights and measures – Imperial & Metric system
    • Calculations involving percentage solutions, alligation, proof spirit and isotonic solutions based on freezing point and molecular weight.
  • Powders:
    • Definition, classification, advantages and disadvantages
    • Simple & compound powders – official preparations, dusting powders, effervescent, efflorescent and hygroscopic powders, eutectic mixtures.
    • Geometric dilutions.
  • Liquid Dosage Forms:
    • Advantages and disadvantages of liquid dosage forms.
    • Excipients used in formulation of liquid dosage forms.
    • Solubility enhancement techniques

UNIT – III  

Monophasic Liquids:

  • Definitions and preparations of Gargles, Mouthwashes, Throat Paint, Eardrops, Nasal drops, Enemas, Syrups, Elixirs, Liniments and Lotions.

Biphasic Liquids:

  • Suspensions:
    • Definition, advantages and disadvantages, classifications, Preparation of suspensions;
    • Flocculated and Deflocculated suspension & stability problems and methods to overcome.
  • Emulsions:
    • Definition, classification, emulsifying agent, test for the identification of type of Emulsion
    • Methods of preparation & stability problems and methods to overcome.

UNIT – IV 

Suppositories:

  • Definition, types, advantages and disadvantages, types of bases, methods of preparations.
  • Displacement value & its calculations, evaluation of suppositories.

 Pharmaceutical Incompatibilities:

  • Definition, classification, physical, chemical and therapeutic incompatibilities with examples.

UNIT – V

Semisolid Dosage Forms:

  • Definitions, classification, mechanisms and factors influencing dermal penetration of drugs.
  • Preparation of ointments, pastes, creams and gels.
  • Excipients used in semi solid dosage forms.
  • Evaluation of semi solid dosages forms

 

Recommended Books: (Latest Editions) 

  • C. Ansel et al., Pharmaceutical Dosage Form and Drug Delivery System, Lippincott Williams and Walkins, New Delhi.
  • Carter S.J., Cooper and Gunn’s-Dispensing for Pharmaceutical Students, CBS publishers, New Delhi.
  • E. Aulton, Pharmaceutics, The Science& Dosage Form Design, Churchill Livingstone, Edinburgh.
  • Indian pharmacopoeia.
  • British pharmacopoeia.
  • Theory and Practice of Industrial Pharmacy,Lea& Febiger Publisher, The University of Michigan.
  • Alfonso R. Gennaro Remington. The Science and Practice of Pharmacy, Lippincott Williams, New Delhi.
  • Carter S.J., Cooper and Gunn’s. Tutorial Pharmacy, CBS Publications, New Delhi.
  • A. Rawlins, Bentley’s Text Book of Pharmaceutics, English Language Book Society, Elsevier Health Sciences, USA.
  • Isaac Ghebre Sellassie: Pharmaceutical Pelletization Technology, Marcel Dekker, INC, New York.
  • Dilip M. Parikh: Handbook of Pharmaceutical Granulation Technology, Marcel Dekker, INC, New York.
  • Francoise Nieloud and Gilberte Marti-Mestres: Pharmaceutical Emulsions and Suspensions, Marcel Dekker, INC, New York.

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